with regards to multiple saves and continues ... Saving a[nd] restarting is not generally recommended for scenarios and should be avoided completely with scenarios with a high density of AI Because AI paths are recalculated from the restart point and trains mid path can[']t always be resolved, it can cause off paths and collisions and even if it doesn't kill the scenario it can cause the scenario to behave differently to the way the author intended. (my underlining)
Although it certainly coincides with my experience, I can't recall ever having come across this information in any users' manual. The biggest problem in following this advice would occur with long-run scenarios such as those on Marias Pass and Donner Pass, but I've run into AI glitches after saving and reloading short scenarios as well. It's something to keep in mind when writing scenarios with lots of AI.