Organizing and enabling assets

I didn't see a thread for short questions/short answers.
When you have collected assets from various sources but for a particular genre/railroad is it possible (or even practical) to put them all in one folder to activate or do you just have to keep track of them and enable them all separately? For example, could I put my NS and CSX assets in one place so it's not necessary to load unneeded models for certain routes, or if I make my own? Or grouping cars by time period?
When you have collected assets from various sources but for a particular genre/railroad is it possible (or even practical) to put them all in one folder to activate or do you just have to keep track of them and enable them all separately? For example, could I put my NS and CSX assets in one place so it's not necessary to load unneeded models for certain routes, or if I make my own? Or grouping cars by time period?