DapperDan wrote:That's exactly what I did today and it worked perfectly. Got Ohio Steel2, Colton Northern, Portland Terminal and the SD45.

Good choices.
Despite being old, Colton Northern is a lot of fun.
Do yourself a favor, though, and go through the scenarios with the scenario editor.
Open the player train's instructions in the timetable view, open each "go via" instruction and change the 0 mph speed to 1 mph.
Well, almost each: not the ones where you have to stop for reversing directions, of course.
At 0 mph, the instruction is a "stop at" instead of a "go via", and it is very annoying to have to stop every minute or so, especially since the markers are so small so it is easy to overshoot.
At the time Mr. Garber made this route, the game's behavior was different.
I also replaced the default SD40 with the LV RS11, and I found it is perfectly suited to this route. But that's just me.